Abstract
Summary
In mice under 18 days of age, encephalitis and death invariably follow intraperitoneal injection of large doses of neurotropic-WS influenza virus. Older mice show varying degrees of resistance to infection. In general, decreased susceptibility is characterized by longer incubation periods and high proportion of survivors. The virus titer in infant mouse brain rises more rapidly and attains a higher level than in adult mouse brain. In addition, the degree of susceptibility may also be a function of the number of virus particles actually reaching the brain after intraperitoneal injection.
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