Abstract
Summary
1. Sixteen diabetic patients exhibiting local skin reactions to insulin as nodules with or without erythema or stinging were tested intradermally with various insulin products, beef and pork protein. 2. Sixteen nondiabetics not using insulin were similarly tested with the same substances. 3. Passive transfer tests with the sera of 5 patients manifesting local reactions to insulin were performed. 4. Skin reactions noted in patients exhibiting local reactions to insulin were no different from those obtained in the control group of nondiabetics, non-users of insulin. 5. The Prausnitz-Küstner passive transfer phenomenon was absent in all 5 instances. 6. It is concluded that local nodules with or without stinging or erythema observed in patients receiving insulin therapy are not due to any antigen-antibody mechanism.
Get full access to this article
View all access options for this article.