Abstract
Summary
A mixture of 2 strains of Type I poliomyelitis virus was adapted to the PRI strain of mice and to cotton rats. The virus could be propagated in certain sublines when either the intraspinal or intracerebral route of inoculation was used. The infectivity of different sublines for mice and cotton rats varied, but the cytopathic titer in tissue culture was of similar magnitude. The passages in PRI mice resulted in a subline completely avirulent for rhesus and cynomolgus monkeys.
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