Abstract
Summary
1. Myochrysin interfered with the therapeutic activity of subtilin in the experimental β hemolytic streptococcus infection of mice. 2. The myochrysin dose required for interference increased with the amount of subtilin used (it varied between 12.5-40 mg/kg). 3. In the Borrelia duttoni infection of mice, subtherapeutic doses of one drug interfered with the therapeutic action of the other, while therapeutic doses of both drugs acted synergistically. 4. Analogously, in the Borrelia obermeieri infection, both interference and synergism were noted. 5. The effect of the combined treatment in the spirochetal infection may vary at different time intervals following treatment.
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