Relationship of Form and Frequency of Experimental Epileptic Discharges to Age

Abstract

Summary

Metrazol and electrically induced seizure activity in the cortex of kittens at various stages of maturation reveals a relation of form and frequency of discharges to age. Focal and non-focal “spike and wave” discharges of frequencies seen in the EEG of the epileptic human infant and child may be reproduced in young animals. With increasing age spikes of faster frequencies replace this slower “spike and waves”. The findings indicate the importance of electro-ontogenetic studies in investigations of the electrical patterns of epileptic seizures.