Abstract
Summary
Using the granuloma-pouch as an indicator, it has been shown that trypsin, given simultaneously with croton oil, causes particularly intense and widespread tissue-damage in the rat. On the other hand, if trypsin is introduced into the inflamed area 5 days after the croton oil, the granulomatous lining, formed under the influence of this chemical irritant, protects the adjacent tissues against otherwise toxic concentrations of this enzyme. The importance of the time-factor, in determining the effect of trypsin upon inflamed tissue, is emphasized.
Get full access to this article
View all access options for this article.