Curare-Like Activity of Some Bis-Fluorenyl-Bis-Quaternary Ammonium Compounds

Abstract

Conclusions

1. The curariform activity of a new series of bis-quaternary ammonium compounds is reported. 2. Moderate increase of activity is obtained by shortening the distance between nitrogen atoms from approximately 15 Å to 9 Å. 3. Replacement of N-ethyl groups with N-methyl in the 6-carbon chain analog decreases both the activity and the subcutaneous absorption in mice, but has no effect on the activity as measured in dogs and rabbits.