Abstract
Summary
Prostigmine is shown to have an antifibrillatory effect in the hypothermic dog. This agent is more effective when given by coronary perfusion than when given intravenously. When ventricular fibrillation occurs in the unprotected animal, coronary perfusion of prostigmine will allow conversion to a normal rhythm by massage and electric shock. It is felt that the antifibrillatory effect of prostigmine is probably due to an accumulation of acetylcholine.
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