Effect of Sedormid on the Developing Chick Embryo. ∗

Abstract

Summary

The inoculation of Sedormid into the yolk sacs or allantoic cavities of 8-day-old embryonated eggs results in the prompt appearance in their allantoic fluids of materials exhibiting red fluorescence in ultraviolet light. These fluorescent materials appear to accumulate progressively with time. The results of quantitative estimations suggest that coproporphyrin and uroporphyrin are responsible for this fluorescence. Treated embryos are smaller than the controls and exhibit red fluorescence of the kidneys, sternum, and long bones under ultraviolet light. Further interpretation of these data must await isolation and characterization of the fluorescent substances.