Abstract
Summary
1. 5-Iodoorotic acid and 5-iodouridine per se are not utilizable for the growth of S. faecalis or L. casei, while in media supplemented with thymine, thymidine or pteroylglutamic acid, the growth of these organisms is not inhibited by iodoorotic acid or iodouridine. 2. Although 5-iodoorotic acid appeared to support the maximal growth of L. bulgaricus 09, evidence was presented that this was attributable to the release of orotic acid from the iodinated derivative. 3. High concentrations of 5-iodoorotic acid inhibited the growth of L. bulgaricus 09, but this could not be reversed by orotic acid. This inhibition was attributed to the formation of iodide ion, since potassium iodide in similar concentrations produced a comparable inhibitory effect on the microorganism.
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