Abstract
Summary
1. Proconvertin preparations were found to function as hyaluronidase inhibitors. The inhibition of hyaluronic acid depolymerization by proconvertin requires a cofactor and is enhanced by prior incubation with platelet material, which, when tested alone, is inactive. 2. Tissue thromboplastin is also shown to inhibit hyaluronidase. This inhibitory activity seems to be inherent mainly in the lipid moiety, and although always associated with the fraction containing the thromboplastic principle, is independent of its activity. 3. It is suggested that the nonspecific serum hyaluronidase inhibitor is associated with a part of the thromboplastic complex of the blood.
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