Abstract
Summary
Rauwiloid? an alkaloidal extract representing the total activity of the root of Rauwolfia serpentina, Benth., was administered orally for 5 days to 15 normo-tensive dogs. The following observations (compared to 15 control animals) were obtained on the sixth day: 1. There was a significant decrease in MAP and heart rate. 2. Eleven of 15 animals were sedated. 3. The pressor response to epinephrine was augmented. 4. The hypotensive and cardio-accelerator effects of isopropylnorepinephrine (Isuprel) were enhanced. 5. The blood pressure rise generally evoked by hypoxia was reversed. 6. The carotid sinus pressor reflex was diminished. 7. Blockade of the primary blood pressure rise elicited by faradization of the afferent vagus occurred; the secondary rise was essentially unaltered. 8. The hypotensive responses to acetylcholine, histamine and efferent vagal faradization were not altered.
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