Abstract
Summary
The type I and type III strains of poliomyelitis adapted to mice by the intraspinal route by Li and Habel(l), and Li and Schaeffer(2) were found to be infective by the intracerebral route for The Prince Henry mice in Australia. Examination of the behavior of the type I strain during the first 12 passages in Prince Henry mice revealed that there was a slight increase in virulence resulting in more than 50% of the animals becoming paralyzed with an average incubation period of 3 days. Nearly every infected mouse was paralyzed in the fore-limbs only. The virus was found in highest concentration in the cervico-thoraeic area of the cord, but was demonstrated in lower concentration in lumbar cord and brain. Monkeys remained asymptomatic following intracerebral inoculation with this strain.
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