Abstract
Summary
There are differences in the reactions of 11-oxygenated and 11-desoxy 17-ketosteroids with the Pincus and Zimmerman reagents. Since those steroids with an 11-oxygen function are probably of adrenal cortical origin, it is possible to estimate the quantity of these two groups of compounds in extracts of urine by applying both tests. It has been shown that in urine from patients with adrenal cortical hyperplasia the ratio of Pincus to Zimmerman reacting 17-ketosteroids is low indicating a large proportion of 11-oxy compounds.
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