Development of Experimental Exophthalmos in Scorbutic Guinea Pigs. ∗

Abstract

Summary

1. Scorbutic thyroidectomized guinea pigs treated with TSH developed exophthalmos as readily as a group of similarly treated animals maintained on an adequate diet. 2. Histologic and histochemical findings in orbital tissues of the scorbutic guinea pigs were identical with those seen in the control group. 3. The increase in water and hexos-amine contents of orbital tissues of exophthalmic animals was as great in those with scurvy as in the group fed an adequate diet. 4. The existence of the scorbutic state does not in itself affect the capacity of the connective tissue to produce the substances which constitute the amorphous interfibrillar ground substance.