Abstract
Summary
1. A histological study was made of the thyroid, testis, liver, muscle, and bone marrow from rats fed diets containing iodinated casein and varying levels of vit. BI2. h'o marked changes were observed in the liver, muscle or bone marrow of the vit. B12- deficient rats, while extensive changes were noted in the thyroid and testes. 2. The degenerative changes in the thyroid gland were more severe with increased time on experiment; however, these changes were only partially counteracted when vit. B12 was fed. 3. Decreased spermatogenetic activity, shrinkage of the seminiferous tubules, and degeneration of interstitial tissues of the testes observed in vit. BIZ-deficient rats were completely counteracted by feeding vit. BIZ. 4. The relationships of these observations to the anti-thyrotoxic factors from liver and pituitary function have been discussed.
We are indebted to Mrs. Sehema Maynard and Mrs. Virginia Bates for assistance in preparation of the slides.
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