Abstract
Summary
The isolated liver of the bull frog is perfused with oxygenated amphibian Ringer glucose solution. The glucose concentration of the perfusate returning from the liver is determined in control experiments and under the influence of histamine, anti-histamine (Antistine) and epinephrine. Histamine and epinephrine cause an increase of the glucose concentration, probably due to enhanced glycogenolysis. Antistine causes a retention of glucose in the hepatic tissue. Antistine inhibits the spontaneous hepatic glycogenolysis as well as the glycogenolysis induced by histamine and epinephrine.
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