Abstract
Summary
1. Based on the reactions of mice of 5 inbred strains sensitized to egg albumin, evidence is presented which indicates a genetic variation in the ability of mice to respond with anaphylactic shock. 2. The response by anaphylaxis was not found to be positively correlated with the amount of circulating antibody, and it is suggested that anaphylaxis in the mouse is not dependent on this antibody. 3. One inbred strain of mouse, C3H, which was found to be significantly more resistant to anaphylaxis, was also more resistant to histamine. A second strain, however, very susceptible to anaphylaxis, was no more sensitive to histamine than any other. 4. No sex difference in sensitivity to histamine or to anaphylaxis was demonstrable.
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