Abstract
Summary
Serotonin (5-hydroxytryptamine) was identified in bovine platelets by the coincidence of its ultraviolet absorption spectrum with that of synthetic serotonin, and by the agreement of analyses based on ultraviolet absorption, Folin-Ciocalteu reaction and pharmacological assay using the rabbit ear and rat uterus. An average of 2.3 μg/mg of dry platelets was found, equivalent to at least 1.7 × 10−9 μg/platelet. This is more than sufficient to account for all of the serotonin found in bovine serum. No other indolic or phenolic substances were found in the platelet extracts.
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