Abstract
Summary
In TTD-treated rats certain vitamins are capable of reversing the inhibition of TTD on alcohol oxidation at the ace-taldehyde level when injected prior to ethanol administration. The effect of two 20 mg doses of TTD can be reversed by 20 but not by 2 mg of the vitamins. Chemicals like propylene glycol, and cystine did not produce reversal. Injection of nicotinamide into TTD-treated rats after ethanol does not relieve or reverse the toxic symptoms. There is damage to the liver of the TTD-treated rats after 21 days, as shown by its impaired ability to transfer hydrogen anaerobically to methylene blue using succinate, citrate and ethanol as substrates. The damage is thought to be produced through the affinity of TTD for the sulfhydryl sites of the enzymes.
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