Abstract
Summary
Methanesulfonyl esters of a series of aliphatic diols, triols and polyglycols were prepared and tested for an ability to inhibit the growth of sarcoma 180 in white mice. Variations in the degree of branching in the carbon chain, or in the degree of substitution at the carbon atoms bearing hydroxyl groups, did not have a uniform effect on either toxicity or tumor inhibitory activity. Significant inhibition of tumor growth could be demonstrated for 5 of the drugs when they were administered at levels causing definite reduction in body weight.
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