Effect of Malonate on Bacteremia Developed in Mice Artificially Infected with Salmonella typhimurium ∗ †

Abstract

Conclusions

These experiments show that malonate injections in mice artificially infected with S. typhimurium results in the development of a bacteremia more than 100 times as severe as that found within the same time period in control mice injected with equal volumes of saline. Malonate injections in the same mice also reduce survival time, apparently because of the fulminating infection which results. The increased severity of the bacteremia accompanying the malonate injections could be due to a) an impairment of the mouse's defense against bacterial infection, b) the establishment of an internal environment within the mouse which favors bacterial reproduction along the lines postulated by Lewis (6), or c) a combination of (a) and (b). The need for additional experiments thus becomes evident.