The Oxidation of Mannitol. ∗

Abstract

Summary

Radioactive mannitol has been administered to rats with the following results: 1. When given orally, about 50% of the mannitol carbon is recovered in the expired CO₂ in 12 hours. 2. With intraperitoneal injection, the mannitol is largely recovered in urine with only 2-3% of the mannitol carbon recovered in the expired CO₂. 3. By injection directly into the portal system by way of the spleen, oxidation comparable to or greater than that obtained by oral administration is obtained. It is concluded from these results that mannitol can be oxidized by the body if it is administered by a route that makes it first available to the liver, as in oral feedings.