Abstract
Summary
1. Increasing the concentration of hyaluronidase by large units resulted in increased spreading activity until a massive concentration of enzyme was used. 2. Highly polymerized hyaluronic acid obtained from Streptococcus pyogenes, bovine vitreous humor, and human umbilical cord had no significant spreading action. 3. Partially depolymerized streptococcal hyaluronic acid had significant spreading action in rabbits, hastened the absorption of a clysis of physiological salt solution in rabbits and facilitated the spread and absorption of an x-ray contrast medium in guinea pigs. 4. Further depolymerization of the streptococcal hyaluronic acid resulted in products that no longer had significant spreading action.
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