Abstract
Summary
Crithidia jasciculata is competitively inhibited by several 2,4-diaminopyrimidine antagonists of folic and folinic acids. These in vitro inhibition patterns obtained in a chemically defined medium parallel the order of relative drug activities obtained in other laboratories on animal infections by any of several species of plasmodia. Poor correspondence exists, however, between bacterial inhibitions in vitro and inhibitions of plasmodi in vivo by these pyrimidines. The results suggest that this flagellate may be preferable to bacteria hitherto used for preliminary in vitro evaluation of antimalarials.
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