Abstract
Summary
1. Cynomolgus monkeys were treated with 5 mg/kilo of sodium monofluoroacetate on the day of, or 3 days following, subcutaneous inoculation of Type 1 poliomyelitis virus. 2. Nine of 42 monkeys which received drug on the Third day of virus resisted clinical infection as did 5 of 23 animals receiving drug on the third day after virus. All control animals became paralyzed. 3. Citrate did not accumulate in brain tissue of drug-treated monkeys suggesting that the action of fluoroacetate was at some site other than the brain. 4. The significance of these findings is discussed.
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