Abstract
Summary
1. A topically acquired indifference of tissue cells towards the action of heat, such as leads to inflammation and necrosis in normal tissues, is described. This indifference was produced by a mild local pre-irritation of tissues with heat immersion of a rat paw in 48°C water for 2 minutes, 15 seconds, or of a rabbit ear in 49°C water for 2 minutes). Heating was always done under compression of the blood vessels. 2. Local pre-irritation obtained by the injection of dextran or egg-white into the rat paw, or by producing a more chronic inflammation with croton oil applied on the rabbit ear, was ineffective in protecting the tissues locally against a subsequent heat exposure given under compression of the blood vessels. 3. After local pre-irritation of the rat paw by heat, a topical protection was observed also against the inflammatory reaction to intraperitoneally injected dextran or egg-white and, to a slight degree, to dextran subcutaneously injected into the paw
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