Abstract
Summary
1. In the rabbit isoniazid was found to pass freely through the placental barrier. 2. In the unanesthetized dog isoniazid appeared in the milk at concentrations equal to or greater than those of the plasma. 3. In the phenobarbitalized dog the concentrations of isoniazid in the submaxillary secretion and the pancreatic juice were found to be at near plasma levels. 4. In both anesthetized and unanesthetized dogs, total isoniazid recovered from urine and bile at the sixth hour following oral administration varied from 12.9 to 46.0%. Biliary recovery was less than one-tenth of the total in the 5 dogs studied.
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