Abstract
Summary
The benzylation of oxytocin by reduction with metallic sodium in liquid ammonia and subsequent treatment with benzyl chloride has been found to result in the formation of an S,S'-dibenzyl derivative which is biologically inactive. The activity has been regenerated by reduction of the benzylated oxytocin with sodium in liquid ammonia and a comparison of the material after oxidation with oxytocin itself has led to the conclusion that the biologically active material so formed represents oxytocin.
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