Abstract
Summary
The color reaction between isonicotinic acid hydrazide (isoniazid) and glutaconic aldehyde liberated from 4-pyridylpyridinium dichloride as described conforms to Lambert-Beer's law and is the basis for a sensitive and rapid method for determination of hydrazides in blood plasma. Blood plasma levels in mice and guinea pigs after oral administration of respectively 5 and 50 mg of isoniazid have been found to reach a maximum within 30 minutes to 2 hours and to fall to low levels within 18 hours.
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