Abstract
Summary
Anti-hyaluronidase agents, i.e. phosphorylated hesperidin, d-alphatocopherol phosphate, and chrondroitin sulfate were shown to be capable of increasing the effectiveness of administered pituitary trophic hormones such as follicle stimulating hormone (FSH) and corticotrophin. A four-fold increase in effectiveness of FSH was attained when the hormone was administered together with the anti-hyaluronidase agents as compared to the injection of the gonadotrophin alone. A similar degree of enhancement was obtained with corticotrophin. The augmentation induced by the anti-hyaluronidase compounds is attributed to the decreased rate of absorption of the hormone from the site of injection.
Get full access to this article
View all access options for this article.