Congenital Hypoproconvertinemia. ∗

Abstract

Summary

Two unrelated patients had a congenital, probably familial, hemorrhagic disorder associated with a prolonged “prothrombin time.” Laboratory examination showed that this prolongation was not due to deficiency of prothrombin, proaccelerin, or fibrinogen, nor to excess of inhibitors. The diagnosis of hypoproconvertinemia was established by the findings of a low “proconvertin index.” by Owren's test, and by the ability of added proconvertin to restore normal prothrombin conversion in vitro. Prothrombin, consumption tests in both cases showed a: moderate but significant decrease.