Elaboration of Steroid Hormones by Surviving Adrenal Tissue Slices Obtained from Thermally Stressed Dogs. ∗

Abstract

Summary

Adrenal slices from dogs saerificed 24 hours after burning showed a marked increase in the elaboration of hormones compared with the values observed for adrenal tissue from normal dogs. Prior treatment of dogs with 7 U.S.P. units of corticotropin per kg also caused the production of more hormone than untreated controls, but the increase in Compound F was significantly less than in the tissue from burned dogs. Adrenal glands from dogs which were sacrificed 72 hours after burning showed a return to control levels of hormone production with the exception of Compound F which was significantly less than the normal value.