Analgetic Activity of Optical Isomers of 3-hydroxy-N-methylmorphinan ∗ and 6-dimethylamino-4,4-diphenyl-3-heptanone. † ‡

Abstract

Summary and Conclusions

1. The relative analgetic potencies of the tartrates of the optical isomers of 3-hydroxy-N-methylmor-phinan and of the hydrochlorides of Methadone were determined in normal human subjects on finger nail bed pain. 2. An inhibitory effect of the dextro isomers on the analgetic activity of the levo isomers and an additive effect of a combination of the levo isomers were demonstrated. 3. An inhibitory effect of the dextro isomers on ethyl alcohol analgesia was observed. 4. The results of this investigation suggest that the mechanism of action of the morphine-type analgetics studied is the same.