Abstract
Summary
1. Tissue nucleotide levels (AA, ADP, ATP, and total purine) of control rats and those injected with 5-adenylic acid have been studied. At the 100 mg injection dose, brain, muscle, liver, and heart show significant increases in adenosine triphosphate. Of these 4 tissues, only liver exhibits a measurable increase in total purine. Kidney shows no effect. The cellular element of blood shows a small but significant increase in adenosine triphosphate, but this is accompanied by a corresponding increase in total purine. 2. The experiments in which 5-adenylic acid, containing radioactive phosphorus is injected into rats shows a maximum accumulation of the label on a weight basis in the adrenal gland followed by liver, heart, kidney, spleen.
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