Abstract
Summary
1. Serial passage of vaccinia virus intracerebrally in mice treated with isatin thiosemicarbazone results in a gradual diminution in the amount of virus demonstrable in the brain. 2. Treatment with isatin thiosemicarbazone fails to protect rabbits inoculated intracerebrally with vaccinia virus. 3. Aliphatic oxime thiosemicarbazones may be as effective as benzene or heterocyclic derivatives as chemoprophylactic agents against vaccinia virus in mice.
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