Abstract
Summary
1. Feeding mice D-, L- or DL-ethionine in a casein-sucrose diet increases the survival rate of mice inoculated intraperi-toneally with Semliki forest virus. A single, large dose of DL-ethionine injected intraperi-toneally within 24 hours preceding viral inoculation by the same route also increases the survival rate. Ethionine does not increase the resistance of mice to Semliki forest virus when the virus is inoculated intracerebrally. Ethionine-treated mice which survive infection usually are immune to the virus. 2. Methionine does not counteract the protective action of ethionine against Semliki forest viral infection in mice. 3. Dichlorophenoxy thiou-racil and closely related materials increase the survival rate of mice inoculated intraperi-toneally with Semliki forest virus. 4. Ben-zimidazole, 2,6-diaminopurine and other purine derivatives tend to decrease the resistance of mice to Semliki forest virus.
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