Abstract
Summary
1. The photolytic oxidation products of PGA could not be implicated in the production in guinea pigs of renal lesions by large parenteral doses of PGA. 2. These lesions were uniformly produced in guinea pigs by the daily administration of 8 mg of PGA (20 mg of PGA/kg) for periods of 6-10 days, and they occurred in occasional animals at a daily dosage of 2 mg (8 mg/kg). 3. Ascorbic acid did not appear to be a factor in the production of the lesions.
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