Abstract
Summary
In the unanesthetized rabbit, tremors of the hind legs and muscle contractions of the gastrocnemius muscle induced by intravenous doses of nicotine tartrate or acetylcholine are not prevented by acute or chronic section of the sciatic nerve. It is concluded that nicotine exerts, in addition to a central action, a separate and distinct by ether inhalation caused a temporary excitation followed by a decrease of approximately 80% in the response to sciatic stimulation. This effect was reversible and disappeared gradually after removal of the anesthetic.
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