Abstract
Summary
1. DHE did not interfere with the glycogenolytic effect of HGF on rabbit liver slices or on hyperglycemia in intact rabbits. Comparable effects of epinephrine in vitro or in vivo were antagonized by DHE. 2. The hyperglycemia induced by cobaltous chloride, which destroys alpha-cells of the pancreatic islets, was prevented by DHE. This hyperglycemia is attributable to sympathetic nerve stimulation. No evidence for the release of HGF was obtained. 3. Blood sugar was maintained at a normal level in rabbits pretreated with cobalt, then fasted and injected with DHE to limit sympathetic action on the liver.
Get full access to this article
View all access options for this article.