Abstract
Summary
1. In spite of its action in blocking mitosis, colchicine does not directly inhibit the synthesis of DNA. During the first 26 hours of treatment, DNA synthesis proceeds at the same rate as in untreated controls. 2. The result of colchicine treatment is a progressive increase in the number of cells belonging to the higher DNA classes, up to 26 hours. 3. Prolonged treatment eventually results in decreased growth.
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