Abstract
Summary
The data demonstrate that cortisone in the dosage range of 2.5-5.0 mg/day can enhance the survival of intact and adrenal-ectomized rats subjected to the stress of experimental pneumococcal infection. The results of bacteremia studies suggest that optimal doses of cortisone operate by enhancing host resistance to the infectious agent. On the other hand, doses larger than 5 mg per rat per day lower the resistance of rats to this infection. Hence, in cortisone therapy, as in the case with certain other hormones, optimum dosage is important and this may vary with different conditions.
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