Angiotonin Induction of Vascular Lesions in Desoxycorticosterone-Treated Rats. ∗

Abstract

Summary

1. Hourly intraperitoneal administration of angiotonin to rats pretreated with DCA and salt elicited edema, convulsions, a positive fluid balance and increased fluid intake, together with proteinuria, visceral hemorrhages and acute necrotizing lesions in small arteries and arterioles. 2. The same series of changes occurred in similarly pretreated rats given renin subcutaneously. 3. We conclude that the vascular lesions elicited by renin in sensitized animals are very likely due to the action of renin as such, effected by liberation of angiotonin and are not, as hitherto seemed possible, attributable to vasculo-toxic factors in renin preparations or to an action of renin independent of formation of angiotonin.