Abstract
Discussion and Summary
The results reported in this paper have shown that prior injections of inactivated interfering virus or RDE into mouse brain resulted in a marked reduction in the incidence of toxic episodes usually associated with intracerebral administrations of concentrated suspensions of influenza viruses. Intracerebral injections of RDE failed to prevent toxic manifestations, however when virus was introduced by an intravenous route. The somewhat greater efficiency of RDE in suppression of toxic manifestations. as compared with inactivated virus, may possibly be a reflection of its position in the receptor gradient,. The fact that both inactivated interfering virus and RDE proved effective in protection of animals against toxic doses of virus introduced into the central nervous system might appear to suggest that intimate contact between virus and susceptible cell was essential for development of toxic reactions. If union of virus and cell is indispensable, it is apparently a fairly rapid process. for injection of RDE two hours after toxic virus failed to modify the incidence of toxic reactions.
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