Abstract
Summary
(1) Chemotherapeutic experiments with a new insoluble derivative of isoniazid, 1,1′-methylenebis (2-isonicotinyl hydrazine), are described which show that this compound which was of very low toxicity possessed marked anti-tuberculous properties in mice infected with M. tuberculosis H37Rv. (2) This substance was evidently absorbed from the intestinal tract as well as from the subcutaneous tissue where it was implanted in the form of a pellet. (3) Although the new compound was found to be 3-4 times less active than isoniazid on the basis of the absolute value obtained for the 50% protective dose, the ratio LD50/PD50 was very favorable (255) due to the low toxicity.
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