Abstract
Discussion and Summary
The results with labeled histamine show that it is not bound reversibly by blood proteins. As found by Parrot et al. (1,2), γ-globulin causes a diminution of the pharmacological activity of histamine solutions, but on the basis of the dialysis-equilibrium experiments this effect cannot be attributed to binding of histamine by the protein. Schayer(5) has pointed out the non-equilibration of guinea pig organs with exogenous histamine in vivo. The present results show that in vitro guinea pig lung is incapable of binding added histamine or of equilibrating added with bound histamine. Apparently, binding of histamine requires formation at the binding site.
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