Transplantation of a Granulosa Cell Tumor into the Spleen of Castrated Rats,Treated with Gonadotrophin. ∗

Abstract

Conclusion and Summary

The results of the present experiments indicate: 1) Ovarian tumors which develop from splenic transplanted ovarian tissue can be successfully re-transplanted. 2. The retransplanted tumor resembles both a granulosa cell and luteum cell neoplasm. 3. Administration of gonadotropin promotes the successful take. 4. It is assumed also that the prolonged stimulation by augmented amounts of gonadotrophic hormones of the hypophysis, to which the spleen grafted animals are subjected, is responsible for the development of the neoplastic growth. Additional subcutaneous injections with gonadotropin enhance the formation of the tumors. 5. Estrogen produced by the graft must be inactivated by the liver, otherwise tumors do not develop. 6. The presence of adhesions between the spleen and surrounding tissues prevents the growth of the transplant.