Cortisone on Oxygen Consumption of Granulation Tissue from the Rabbit

Abstract

Summary

The oxygen consumption (Q0₂) of pooled dermal and granulation tissue slices from 2.5-3.5 kg male white rabbits were studied by the Warburg technic. The rabbits were divided into 3 groups: (A) Those subjected to dermal injury. (B) Those subjected to dermal injury, but in addition receiving pre- and post-operative cortisone treatment, i.e., 25 mg/day. (C) Those animals subjected to a sham operation. 1. “Normal” uninjured dermal slices give a mean endogenous Q0₂ value of 0.27 ± 0.02 (Group C, Table I). 2. Slices from untreated granulation tissues (Group A) show an increase of 396% over their control (Group C). 3. Slices from cortisone-treated granulation tissue (Group B) give only a 67% increase over the control (C), or a 66% decrease when compared with untreated granulation tissue (A). 4. The implications of these results are discussed.