Abstract
Summary
Intramuscular injections of a soluble cortisone are much superior to the microcrystalline suspensions commercially available in affording protection to the 24-hour adrenalectomized rat infused with dextran. The amount of the soluble steroid required to give adequate protection is 30 times less than that found necessary when the suspension is used and the requisite time for prophylactic fore-treatment is reduced from 5 days to 6 hours. The procedure employed in these experiments can be utilized as the basis for a simple screening test for compounds with cortisone-like activity.
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