Abstract
Summary
Skin melanophores of freshly amputated tadpole tails expand when placed in solutions of ACTH. An assay for rapid estimation of this melanophore-expanding activity of ACTH preparations has been developed, using USP corticotropin as the Reference Standard. All ACTH preparations tested showed this activity. Corticotropin B; the most highly purified preparation available, showed the highest degree of melanophore-expanding activity and was also the most potent in causing adrenal ascorbic acid depletion.
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